Recent publications
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“Characterization of Endogenous and Extruded H2S and Small Oxoacids of Sulfur (SOS) in Cell Cultures” Scrivner, O.; Kumar, M.R.; Sorokolet, K.; Wong, A.; Kebaara, B.; Farmer, P.J. ACS Chem. Bio. 2021, 16(8), 1413-1424; https://doi.org/10.1021/acschembio.1c00257
“Expanding the Reactive Sulfur Metabolome: Intraccellular and Efflux Measurements of Small Oxoacids of Sulfur (SOS) and H2S in Human Primary Vascular Cell Culture” Scrivner, O.; Ismaeel, A; Kumar, M.R.; Sorokolet, K,; Koutakis, P.; Farmer, P.J. Molecules. 2021, 26(23), 7160; https://doi:10.3390/molecules26237160
“Characterization of Polysulfides, Polysulfanes, and Other Unique Species in the Reaction between GSNO and H2S” Kumar, M.R.; Farmer, P.J. Molecules. 2019, 24(17), 3090; https://doi.org/10.3390/molecules24173090
“Oxidative Stress and Arterial Dysfunction in Peripheral Artery Disease” Ismaeel, A.; Brumberg, R.S.; Kirk, J.S.; Papoutsi, E.: Farmer, P.J.; Bohannon, W.T.; Smith, R.S.; Eidson, J.L.; Sawicki, I.; Koutakis, P. Antioxidants 2018, 7, 145; doi.org/10.3390/antiox7100145 PMID:30347720
“Reactivities of Aromatic Protons in Crude Oil Fractions toward Br2 Tagging for Structural Characterization by Nuclear Magnetic Resonance and Electron Paramagnetic Resonance Spectroscopy and Mass Spectrometry” Spiegel, M.T.; Anthony, I.; Brantley, M.; Hassell, A.; Farmer, P.J.; Solouki, T. Energy and Fuels, 2018, 32 (10), pp 10549–10555.DOI: 10.1021/acs.energyfuels. 8b02342doi:10.1021/acs.energyfuels.8b02342
“Synthesis of Transition Metal Selenomaltol Complexes” Spiegel, M.T.; Hoogerbrugge, A.; Truksa, S.; Smith, A.G.; Shuford, K.L.; Klausmeyer, K.K.; Farmer, P.J. Dalton Transactions, 2018, 47, 9030-9037. DOI: 10.1039/C8DT01170B PMID:29927448
”The reaction between GSNO and H2S: on the generation of NO, HNO and N2O” Kumar, M.R.; Clover, T.; Olaitan, A.D.; Becker, C.; Solouki, T.; Farmer, P.J. Nitric Oxide, 2018, 77, 96-105. doi.org/10.1016/j.niox.2018.04.012 PMID:29704568
“Oxidative Stress and Antioxidant Treatment in Patients with Peripheral Artery Disease”Koutakis, P.; Ismaeel, A.; Farmer, P.; Purcell, S.; Smith, R.; Eidson, J.; Bohannon, W. Physiol. Rep. 2018, e13650. doi: 10.14814/phy2.13650. DOI:10.14814/phy2.13650
“Mechanistic Investigations of Photo-induced Oxygenation of Ru(II) Bis-bipyridyl Flavonolate Complexes” Han, X.; Kumar, M.R.; Hoogerbrugge, A.: Klausmeyer, K.K.; Ghimire, M.M.: Harris, L.M.; Omary, M. A.; Farmer, P.J. Inorg. Chem. 2018 57 (5), pp 2416–2424. DOI:10.1021/acs.inorgchem.7b01384 PMID:29461051
“Synthesis, crystal structures, and characterization of the complexes of the bulky ligand 2,6-bis(3',5'-diphenyl)pyrazolylpyridine with ruthenium, rhodium, and palladium” Jackson, M.T.; Duncan, N.C.; Rich, B.; Jones, M.E.; Brien, K.E.; Spiegel, M.; Farmer, P.J.; Klausmeyer, K.K.; Garner, C.M. Polyhedron, 2018 139, 308-312.
“Chemical trapping and characterization of small oxoacids of sulfur (SOS) generated in aqueous oxidations of H2S” Kumar, M.R.; Farmer, P.J. Redox Biol. 2018, 14, 485-491. doi.org/10.1016/j.redox.2017.10.012 PMID:29096321
“First row metal complexes of the hindered tridentate ligand 2, 6-bis-(3’, 5’-diphenylpyrazolyl) pyridine” Jackson, M.T.; Spiegel, M.; Farmer, P.J; Duncan, N.C.; Rich, B.; Jones, M.E.; Brien, K.E.; Klausmeyer, K.K.; Garner, C.M. Inorganica Chemica Acta, 2018 473, 180-5. doi.org/10.1016/j.ica.2017.12.032
“Trapping Reactions of the Sulfenyl and Sulfinyl Tautomers of Sulfenic Acids” Kumar, M.R.; Farmer, P.J. ACS Chem. Biol. 2017, 12, 474–478. PMID: 27984696 DOI:10.1021/acschembio.6b00980
“Characterization of the Initial Intermediate Formed during Photoinduced Oxygenation of the Ruthenium(II) Bis(bipyridyl)flavonolate Complex” Han, X.; Klausmeyer, K.K.; Farmer, P.J. Inorg. Chem. 2016 55, 7320-7322.
“Spectroscopic NMR characterizations of HNO adducts of ferrous heme proteins” Kumar, M.R.; Farmer, P.J. The Chemistry and Biology of Nitroxyl (HNO), F. Doctorovich, P.J. Farmer, M. Marti eds., Elsevier, Amsterdam, Netherlands 2016, Chp. 14, pp. 269-286.
“Global kinetic analysis and singular value decomposition methods applied to complex multicomponent reactions of HNO” Zapata, A.L.; Kumar, M.R.; Farmer, P.J. The Chemistry and Biology of Nitroxyl (HNO), F. Doctorovich, P.J. Farmer, M. Marti eds., Elsevier, Amsterdam, Netherlands 2016, Chp. 15, pp. 287-304
“HNO as an Oxygen Substitute in Enzymes” Han, X.; Farmer, P.J. The Chemistry and Biology of Nitroxyl (HNO), F. Doctorovich, P.J. Farmer, M. Marti eds., Elsevier, Amsterdam, Netherlands 2016, Chp. 16, pp. 305-320.
“Nitroxygenation of quercetin by HNO” Xiaozhen Han, Murugaeson R Kumar, Patrick J Farmer. Tet. Lett. 2016, 57, 399.
“Amyloids, melanins and oxidative stress in melanomagenesis” Feng Liu‐Smith, Carrie Poe, Patrick J Farmer, Frank L Meyskens. Exp. Dermatol. 2015, 24, 171.
“Ligand-based photooxidations of dithiomaltolato complexes of Ru (II) and Zn (II): photolytic CH activation and evidence of singlet oxygen generation and quenching” Britain Bruner, Malin Backlund Walker, Mukunda M Ghimire, Dong Zhang, Matthias Selke, Kevin K Klausmeyer, Mohammad A Omary, Patrick J Farmer. Dalton Trans. 2014, 43, 11548.
“The Intricate Puzzle of HNO Chemistry” Patrick J. Farmer, Fabio Doctorovich. J. Inorg. Biochem. 2013, 118, 107.
“A singular variable decomposition approach for kinetic analysis of reactions of HNO with myoglobin” Zapata, A.; Pervitsky, D.; Kumar, M.R.; Farmer, P.J. J. Inorg. Biochem. 2013, 118, 171-178.
“Synthesis and characterization of lithium nitroxyl” Switzer, C.H.; Miller, T.W.; Farmer, P.J.; Fukuto, J.M. J. Inorg. Biochem. 2013, 118, 128-133.
“Studies on synthetic and natural melanin and its affinity for Fe(III) ion” Costa, T. G.; Younger, R.; Poe, C.; Farmer, P.J.; Szpoganicz, B. Bioinorg. Chem. Appl. 2012, 712840, 9 pp.
“Direct oxygen imaging in titania nanocrystals” Lu, W.; Bruner, B.; Casillas, G.-C.; Mejía-Rosales, S.: Farmer, P.J.; Jose-Yacaman, M. Nanotechnology, 2012, 23.
“Probing motional behavior of eumelanin and pheomelanin by solid-state NMR: new insights into the pigment properties” Thureau, P.; Ziarelli, F.; Thévand, A.; Martin, R.W.; Farmer, P.J.; Viel, S.; Mollica, G. Chem. Euro. J. 2012, 18:10689-700.
Kinetic Characterization of a Slow-Binding Inhibitor of Bla2: Thiomaltol” Schlesinger, S.R.; Bruner, B.; Farmer, P.; Kim, S.-K. J. Enz. Inhib. Med. Chem. 2013, 28, 137-142.
“Large scale synthesis of V-shaped rutile twinned nanorods” Lu, W.; Bruner, B.; Garcia, G.-C.; He, J.: Jose-Yacaman, M.; Farmer, P.J. CrystEngComm, 2012, 14, 3120-3124.
“Nitrosyl hydride (HNO) replaces dioxygen in nitroxygenase activity of manganese quercetin dioxygenase” Kumar, M.R.; Zapata, A.; Ramirez, A.J.; Bowen, S.K.; Francisco, W.A.; Farmer, P.J. PNAS USA, 2011, 108, 18926-31.
“The Coordination Chemistry of HNO: From Warren Roper to Hemoglobin” Farmer, P.J.; Kumar, M.R; Almaraz, E. Comm. Inorg. Chem. 2010, 31, 1–14.
"Reactions of HNO with Heme Proteins: New Routes to HNO−Heme Complexes and Insight into Physiological Effects." Murugaeson R. Kumar, Jon M. Fukuto, Katrina M. Miranda and Patrick J. Farmer Inorg. Chem., 2010, 49 (14), pp 6283–6292
“Disulfiram, metals, and melanoma.” Walker, M.B.; Edwards, K.; Farmer, P.J. J. Chem. Educ., 2009, 86, 1224-1226.
“Pattern of Expression and Substrate Specificity of Chloroplast Ferredoxins from Chlamydomonas reinhardtii.” Terauchi, A.M.; Lu, S.-F.; Zaffagnini, M.; Tappa, S.; Hirasawa, M.; Tripathy, J.N.; Knaff, D.B.; Farmer, P.J.; Lemaire, S.D.; Hase, T.; Merchant, S.S. J. Biol. Chem., 2009, 284, 25867-25878.
“Photo- and thermal-induced linkage isomerizations in a peroxydithiocarbamate-Ru complex.” Ng, S.; Walker, M.B.; Farmer, P.J. Inorg. Chim. Acta, 2009, 362, 4013-4016.
“The effects of nitroxyl (HNO) on soluble guanylate cyclase activity: Interactions at ferrous heme and cysteine thiols.” Miller, T.W.; Cherney, M.M.; Lee, A.J.; Francoleon, N.E.; Farmer, P.J.; King, S.B.; Hobbs, A.J.; Miranda, K.M.; Burstyn, J.N.; Fukoto, J.M. J. Biol. Chem., 2009, 284, 21788-21796.
“Nitrosyl Hydride (HNO) as an O2 Analogue: Long-Lived HNO Adducts of Ferrous Globins.” Kumar, M.R.; Pervitsky, D.; Chen, L.; Poulous , T.; Kundu, S.; Hargrove, M.S.; Rivera, E.J.; Diaz, A.; Colon, J.L.; Farmer, P.J. Biochemistry, 2009, 48, 5018-5025.
“Melansomal damage in normal human melanocytes induced by UVB and metal uptake-A basis for the pro-oxidant state of melanoma.” Gidanian, S.; Mentelle, M.; Meyskens, F.L.; Farmer, P.J. Photochem. Photobiol., 2008, 84, 556-564.
“Unexpected C-H Activation of Ru(II)-Dithiomaltol Complexes upon Oxidation.” Backlund, M.; Ziller, J.; Farmer, P.J. Inorg. Chem., 2008, 47, 2864-2870.
“Photolysis of the HNO Adduct of Myoglobin: Transient Generation of the Aminoxyl Radical.”Pervitsky, D.; Immoos, C.; van der Veer, W.; Farmer, P.J. J. Am. Chem. Soc., 2007, 129, 9590-9591.
“New perspectives on melanoma pathogenesis and chemoprevention.” Meyskens, F.L.; Farmer, P.J.; Yang, S.; Anton-Culver, H. Recent Res. Cancer, 2007, 174, 191-195.
“Oxygenation of Zinc Dialkyldithiocarbamate Complexes: isolation, characterization and reactivity of the stoichiometric oxygenates.” Brayton, D; Tanabe, K; Khiterer, M; Kolahi, K; Ziller, J; Greaves, J; Farmer, P.J. Inorg. Chem., 2006, 45, 6064-6072.
“The interaction of nitric oxide with distinct hemoglobins differentially amplifies endothelial heme uptake and heme oxygenase-1 expression.” Foresti, R.: Bains, S.; Sulc, F.; Farmer, P.J.; Green, C.J.; Motterlini, R. J. Pharmacol. Exp. Ther., 2006, 317, 1125-1133.
“A novel heterocyclic atom exchange reaction with Lawesson’s reagent: one-pot synthesis of dithiomaltol.” Brayton, D.; Faith E. Jacobsen, F.E.; Cohen, S.M.; Farmer, P.J. Chem. Commun., 2006, 2, 206 – 208.
“The Putidaredoxin Reductase-Putidaredoxin Electron Transfer Complex: Theoretical and Experimental Study.” Kuznetsov, V. Y.; Blair, E.; Farmer, P. J.; Poulos, T.L.; Pifferitti, A.; Sevrioukova, I.F. J. Biol. Chem. 2005, 280, 16135-16142.
“The Effect of Stacking and Redox State on Optical Absorption Spectra of Melanins- a comparison of theoretical and experimental results.” Stark, K.B.; Gallas, J.M.; Zajac G.W.; Golab, J.T.; Gidanian, S.; McIntire, T.; Farmer, P.J. J. Phys. Chem. B. 2005 ,109, 1970-1977.
“Bonding in HNO-Myoglobin as Characterized by X-Ray Absorbance and Resonance Raman Spectroscopies.” Immoos, C.E.; Sulc, F.; Farmer, P.J.; Czarnecki, K.; Bocian, D.F.; Levina, A.; Aitken, J.B.; Armstrong, R.S.; Lay, P.A. J. Am. Chem. Soc.; 2005, 127, 814 – 815.
“Coordination Chemistry of the HNO Ligand with Hemes and Synthetic Coordination Complexes.” Farmer, P.J.; Sulc, F. J. Inorg. Biochem. 2005, 99, 166-184.
