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    The Farmer Research Group - Bulletin Board

    Check below for upcoming events, news, and updated information on the Farmer Research Group. Use the link to the right to add this feed to your RSS.

    Thursday
    Aug112022

    Follow up paper on SOS in vascular cells

    Expanding the Reactive Sulfur Metabolome: Intracellular and Efflux Measurements of Small Oxoacids of Sulfur (SOS) and H2S in Human Primary Vascular Cell Culture

    Ottis Scrivner, Ahmed Ismaeel, Murugaeson R. Kumar, Kristina Sorokolet, Panagiotis Koutakis, Patrick J. Farmer

    Molecules 2021, 26(23), 7160

     

    Highlights

    • H2S and SOS are produced and extruded in smooth muscle cells 20 x that in endothelial cells

    • Hypoxia increased the generation of sulfenic acids while decreasing hydrogen sulfide

    Thursday
    Aug112022

    Ottis' paper in Metallomics

     

    Years in the making !!

    Conclusions

    Treatment of melanoma with Cu, Zn or Fe thiomaltol complexes causes a strong apoptotic response in melanoma, with Cu by far most active.

    Apoptosis increases with superstoichiometric additions of Cu at the same Htma dosing, which correlates with an increase in intracellular Cu. 

    Cu/Htma treatment causes rapid morphological changes in melanoma cells.

    Cu/Htma was shown to rapidly accumulate in lysomes preceding apoptosis, using EM and confocal microscopy.

    Use of fluorescent dithiomaltol Httma shows its accumulation in extracellular membrane and lysosomes.

    Cu/Htma treatment inhibits proteasomal activityconcurrent with cell death.

     

    Wednesday
    Nov062019

    Ravi has another one... 

    Dr. Kumar has another publication on biochemical sulfur chemistry, this one is a followup on GSNO reactivity, “Characterization of Polysulfides, Polysulfanes, and Other Unique Species in the Reaction between GSNO and H2S” Kumar, M.R.; Farmer, P.J. Molecules. 2019, 24(17), 3090;

    Wednesday
    Nov062019

    Alumnus does good! 

    Farmer lab alum Prof. Michael Cohen from U Oregon Health and Science gave a talk at UC Irvine and saw many familiar faces, including Prof. Ev Fleischer who used to be active in our lab.

    Wednesday
    Nov062019

    Congrats again, Mike!

    Michael Spiegel has defended and will graduate in December... his last paper was a long collaboration with the Solouki group on characterizing complex mixtures of asphaltenes, published in Energy and Fuels, 2018, 32 (10), pp 10549–10555